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Comment 14

Please cite this contribution as follows: Ilya [Bozo]. Alexey, I see you are quite well versed in different. Blog comment, Maximow Award contest, June 2012. Cell Ther Transplant/Maximow Award, June 2012;blog-comment_14. doi:10.3205/maximowaward_2012_blog-comment_14

This contribution is provided under the following license: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Ilya. June 4, 2012 at 5:05 pm

Alexey,
I see you are quite well versed in different methods of HSC processing in vitro. Despite this, you take the discussion away from the main issue which was indicated in the title of blog. There are not questions regarding the methodology of cell processing, more precisely, these questions are minor. Characteristics of HSCs populations is the main point of our disagreement.

In my opinion a true HSC is the initial point for all differons of blood cells (and some other kind of cell, for ex. fibroblasts, etc.). I do not exclude the possibility that HSC population is heterogeneous. However, I am against the separation that you indicated and called as generally accepted.

You said: “We don’t consider the “biased HSC” as pre-commited cells, because they retain multilineage repopulation capability”. Then please tell us what are you talking about “bias” if each of these subpopulations have multilineage repopulation capability? So, it have self-renewal, multilineage differentiation, and a similar pattern of markers. I said earlier about this contradiction in your words.

This contribution is provided under the following license: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

Please cite this contribution as follows: Ilya [Bozo]. Alexey, I see you are quite well versed in different. Blog comment, Maximow Award contest, June 2012. Cell Ther Transplant/Maximow Award, June 2012;blog-comment_14. doi:10.3205/maximowaward_2012_blog-comment_14

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