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Comment 12

Please cite this contribution as follows: Please cite this contribution as follows: Alexey [Bersenev]. Kshama, We don’t consider the “biased HSC” as pre-commited. Blog comment, Maximow Award contest, May 2012. Cell Ther Transplant/Maximow Award, May 2012;blog-comment_12. doi:10.3205/maximowaward_2012_blog-comment_12

This contribution is provided under the following license: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Alexey. June 1, 2012 at 4:20 pm

Kshama,
We don’t consider the “biased HSC” as pre-commited cells, because they retain multilineage repopulation capability. Now it’s clear for myeloid-biased HSC. Both Nakauchi (Morita 2010) and Eaves groups (2007, 2009, 2012) confirmed that myeloid-biased HSC can give robust multilineage engraftment in secondary transplant. It still not clear for lympoid-biased (Morita 2010 – yes, Eaves group – no or under?), we need more data. So, it’s not black and white.

In terms of medical practicality to call it “HSC”. Even though, in the clinic, we always use a mix stem and progenitor cells, we can still confidently use and call it HSC transplant/ therapy if therapeutic effects underlie HSC function and if we can detect donor-derived multilineage repopulation and engraftment for many years or life-long. In many cases in hematology-oncology we don’t need donor’s HSC function, we need progenitor cells for resque ablated marrow, save a patient from neutropenia and we need T-cells for graft-versus-tumor effect. So, sometimes hematology-oncology patients can get rid of disease without donor’s HSC. In this case you can call it “cell therapy” or “progenitor cell therapy” or “T-cell therapy”, depends on mechanisms. Frequently stem cell labs in the hospitals label a graft as “HPC” product = “hematopoietic progenitor cells”.

In terms of HSC markers, CD34 is only on of HSC markers for human, but mouse CD34+ will not engraft long-term. And with SLAM situation is quite opposite – in mouse LSK/SLAM (or E-SLAM) are HSC, but in human SLAM HSC are progenitors. You can read here -
stemcellassays.com/2011/04/the-brief-history-of-phenotype-dissection-of-hematopoietic-stem-cells/   
and
stemcellassays.com/2011/05/the-brief-history-of-phenotype-dissection-of-hematopoietic-stem-cells-an-update/   

This contribution is provided under the following license: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

Please cite this contribution as follows: Please cite this contribution as follows: Alexey [Bersenev]. Kshama, We don’t consider the “biased HSC” as pre-commited. Blog comment, Maximow Award contest, May 2012. Cell Ther Transplant/Maximow Award, May 2012;blog-comment_12. doi:10.3205/maximowaward_2012_blog-comment_12

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