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Comment 05

Please cite this contribution as follows: Ilya [Bozo]. I still do not agree with Alexey. If HSC has. Blog comment, Maximow Award contest, May 2012. Cell Ther Transplant/Maximow Award, May 2012;blog-comment_05. doi:10.3205/maximowaward_2012_blog-comment_05

This contribution is provided under the following license: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

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Ilya. May 30, 2012 at 5:09 am

I still do not agree with Alexey. If HSC has focus in a particular direction of differentiation (myeloid-, lymphoid- biased, etc.), then it should not be considered HSCs, but as closest of its derivatives. Of course, the minimal but sufficient for clinical use methods of obtaining HSC does not allow us to accurately separate the true HSC from their closest derivatives. Moreover, for routine clinical practice such separation may not be necessary. However, in general biological sense, the population of HSCs are still more homogeneous.

All terminological problems are caused by different interpretation of new data. New data (in respect of immunophenotype, differentiation potential, etc.) can be used for division of HSC to a lot of subpopulations or for purification of HSC from the nearest derivatives. As for me, I like the second option, which is more correlated with the terms of the classical school of histology.

This contribution is provided under the following license: Creative Commons Attribution 3.0 Unported (CC BY 3.0)

Please cite this contribution as follows: Ilya [Bozo]. I still do not agree with Alexey. If HSC has. Blog comment, Maximow Award contest, May 2012. Cell Ther Transplant/Maximow Award, May 2012;blog-comment_05. doi:10.3205/maximowaward_2012_blog-comment_05

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